Intestinal transcriptome analysis of soybean-induced enteritis in Atlantic salmon

NEWS

A study led by the Nord University (Bodø, Norway) examined the dysregulation of intestinal barrier functions in Atlantic salmon fed a soy saponins-rich diet

The study assessed changes in micromorphology, transcriptome of the distal intestine (DI) and whole blood cells in salmon fed a pro-inflammatory (SO) and a control (CO) diet. The novelty of the current study lies in the adoption of RNA-Seq to clearly delineate the molecular changes evoked during inflammation. The soybean–soy saponin combination induced DI inflammation in Atlantic salmon. The transcriptional changes associated with inflammation could be linked to disturbances in transport mechanisms as well as drug and taurine and hypotaurine metabolisms and steroid biosynthesis in the DI of the fish. As part of its continuous effort to generate new knowledge on the underlying mechanisms associated to the nutritional modulation of gut health in fish, SPAROS has formulated and manufactured the experimental diets used in this trial. This study was undertaken as part of a collaborative project “Molecular studies on the intestine of Atlantic salmon” funded by DSM Nutritional Products (Switzerland).

Link to the article in here.