A study led by the Nord University (Bodø, Norway) evaluated the effect of diets containing soybean meal in the intestinal inflammation of zebrafish juveniles. The effect of dietary supplementation with yeast β-glucans to counter the inflammatory response was also assessed.
A transcriptomic approach allowed verifying the effect of three tailored diets in the expression of several intestinal barrier function-related genes. Diets were produced by SPAROS based on the following concepts: Control (CZ; rich in marine protein and lipid sources), pro-inflammatory diet (CP; containing 50 % of soybean meal and higher levels of saturated fat and cholesterol) and a diet similar to CP (PM), supplemented with cell wall baker´s yeast (Saccharomyces cerevisiae) β-glucans (β- glucan supplementation of 1,000 mg/kg feed). Results showed the intestinal transcriptome of zebrafish fed the soybean-based diet (CP) revealed the modulation of several genes related to barrier function, oxidative stress, mitochondrial protein folding, cell cycle, DNA damage and repair, immune status and reproduction. Furthermore, positive histomorphological changes were observed on the intestinal mucosal barrier of fish fed the diet supplemented with β-glucans. In overall, this study shows the positive contribution of SPAROS tailored diets to generate new knowledge to study the underlying mechanisms related to gut health and dietary modulation in fish.
You can read the article here.
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Tatiana Poletto
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Tatiana Poletto2025-09-02 14:57:102025-09-02 14:57:10Join Us for a First Look at OptiFeeSH
